Current report filing

Note 10 - Collaborative Agreements

v3.19.1
Note 10 - Collaborative Agreements
9 Months Ended
Sep. 30, 2018
Notes to Financial Statements  
Collaborative Agreements [Text Block]
10.
Collaborative agreements:
 
The Company enters into research, development and license agreements in the ordinary course of business where the Company receives research services and rights to proprietary technologies. Milestone and royalty payments that
may
become due under various agreements are dependent on, among other factors, clinical trials, regulatory approvals and ultimately the successful development of a new drug, the outcome and timing of which is uncertain.
 
Under the license agreement with CrystalGenomics, the Company has obligations for development milestones of
$16
million related to the initiation of Phase
2
and pivotal clinical trials, and regulatory milestones totaling
$44
million. The Company also has an obligation to pay royalty payments on sales of commercialized product. The timing of any milestone or royalty payments that
may
become due is
not
yet determinable.
 
On
June 13, 2018,
the Company entered into a license agreement with CrystalGenomics to gain an exclusive license to
CG806
in China. The Company has future obligations of development milestones of
$6
million related to approval of an Investigational New Drug (“IND”) and to the initiation of Phase
2
and pivotal clinical trials, and regulatory milestones totaling
$20
million. The Company also has an obligation to pay sales milestones and royalty payments on sales of commercialized product. The timing of any milestone or royalty payments that
may
become due is
not
yet determinable.
 
On
March 7, 2018,
we entered into an exclusive global license agreement with Ohm Oncology (OHM), for the development, manufacture and commercialization of APL-
581,
as well as related molecules from our dual bromodomain and extra-terminal domain motif (BET) protein and kinase inhibitor program. Under the agreement, we will retain reacquisition rights to certain molecules, while OHM/LALS will have the rights to develop and sublicense all other molecules. We have received
two
nominal upfront cash payments and are eligible to receive up to
$125
million of additional payments based on the achievement of certain development, regulatory and sales milestones, as well as significant royalties on future sales generated from the program, if any.